22 and 23 It is important to mention here Elores was resistant only to those strains which were positive with TEM-50, OXA-11 and CTXM-9, whereas ceftriaxone was resistant to all isolates which were positive with MBL genes including NDM-1, VIM-1, KPC-2, IMP-1 and ESBL genes such as TEM-50, SHV-10, OXA-11 and CTXM-9. However, Elores appeared to be highly susceptible to all isolates positive with MBL genes NDM-1, VIM-1, KPC-2, IMP-1. Results obtained in the present study, together with microbiological evaluation study suggest that Elores should be considered as antibacterial agents for the treatment of LRTI and UTI caused by these organisms. All
authors have none to declare. Authors are thankful to sponsor, Venus Medicine Research Center India and Germany, for providing assistance to carry out this study. Also thanks to all investigators, centers and Selleckchem A1210477 CCI-779 datasheet patients who participated in the study. “
“A number of herbal medicines are prepared by decoction process. Therefore, quality control of herbal drugs is very difficult due to presence of wide range of polar compounds. The quality data on the safety and efficacy of traditional medicine are far from sufficient to meet the
criteria needed to support its worldwide use. Due to lack of adequate or accepted research, even after existence and continued use over many centuries traditional medicines has not been recognized in most countries (World Health Organization, 2000). In addition, factors like collection time, geographical variations and different whatever processing methods leads to chemical variations in the herbal
drugs and put another challenge.1 and 2 Many techniques has been reported to monitor the quality parameters, which includes thin layer chromatography,3 high performance thin layer chromatography, gas chromatography,4 high performance liquid chromatography mass spectrometry5 and 6 and others.7 Most recommended techniques for quality control of herbal drugs are chemical fingerprints obtained by chromatographic techniques being the representative of “chemical integrities.” The LCMS fingerprints of metabolites of clinical proven efficient drugs may be the best option for the standardization of herbal drug.8 and 9 Terminalia tomentosa (Roxb.) of family Combretaceae is a large tree found in deciduous forests and widely distributed in India and Burma. T. tomentosa bark decoction has been mentioned by Charaka Samhita for treatment of rheumatism, fever, urinary diseases and diabetes. 10T. tomentosa bark is astringent and used in atonic diarrhea and generally for indolent ulcers. As an incense and cosmetic bark is also used for dyeing black and yields a gum. Trees of this genus are known especially for secondary metabolites constituents, such as cyclic triterpenes and their derivatives, flavonoids, tannins and other aromatics. T. tomentosa is an important plant used in traditional medicines but very less studied plant in the genus of Teminalia.