Exploratory factor analysis was conducted. Internal
consistency, concurrent validity, discriminant validity, homogeneity of items, and responsiveness were tested.
Out of the 125 children enrolled from 48 childcare centres, 55 children had ILI (total 75 ILI episodes). Care-ILI-QoL was VX-689 ic50 reduced from 25 to 16 items covering four factors: Daily Activities, Perceived Support, Social Life, and Emotions (Cronbach’s alphas 0.90, 0.92, 0.78, and 0.72, respectively). Care-ILI-QoL has satisfactory concurrent and discriminant validity, good internal consistency, and excellent responsiveness. Total QoL and factor scores correlated well with SF-12v2 scores. Total QoL scores were significantly lower in parents who perceived their child as very/extremely sick, sacrificed 10 hours or more in work or recreation in caring for the child, or whose
child had two or more general practitioner visits. Total QoL and factor scores were significantly higher after the child had recovered than when the child had ILI.
Care-ILI-QoL is the first LY2835219 manufacturer ILI-specific QoL instrument for parents and is demonstrated to be valid and reliable in a developed country setting where the child is affected by ILI. It has the potential to be applied in clinical and research settings to assist measurement of disease burden, as a needs assessment tool for resources or to inform policy changes.”
“This study examined depressive symptoms, sleep disturbance, and quality of life in 35 patients with Parkinson’s disease. Results showed that nocturnal sleep disturbance, depressive symptoms, and motor disease severity accounted for over two-thirds of the variance in quality of life scores. Depression was the largest predictor of quality of life, uniquely explaining 21% of the variance. Nocturnal sleep disturbance was associated with depressive symptoms as well as with daytime sleepiness. Overall, these data highlight the need to screen patients for even mild levels of depression because its relationship with sleep and quality of life are evident early in the disease course.
(The
Journal of Neuropsychiatry and Clinical Neurosciences 2010; 22:384-389)”
“The present study was conducted to investigate the prevalence PCI-32765 in vitro of mucosal injury in patients taking low-dose aspirin in Japan and examine the effect of gastric mucoprotective drugs on aspirin-related gastroduodenal toxicity. We selected 530 patients who had taken low-dose aspirin for 1 month or more after undergoing esophagogastroduodenoscopy from 2005 through 2006 at Teikyo University Hospital, Tokyo, Japan. Endoscopic records were retrospectively reviewed to determine the presence of massive bleeding and mucosal injury (ulcer or erosion). The influence of clinical factors, including co-administration of gastroprotective drugs, was also examined. Hemorrhage was observed in 25 patients (3.7%) and mucosa! injury (36.