Initially, following two-stitch neurorrhaphy, 40 limbs (20 rats)

Initially, following two-stitch neurorrhaphy, 40 limbs (20 rats) underwent wrapping in 7- or 10-μm honeycomb film, cast film, no wrapping, or extra two-stitch neurorrhaphy CP-673451 solubility dmso (8 limbs each). Breaking strength was tested 2 days postoperatively. Another 30 limbs

(15 rats) then underwent wrapping in 7- or 10-μm honeycomb film, cast film, no wrapping, or sham operation (six limbs each). Histological and functional analyses were performed 6 weeks postoperatively. Breaking strength was significantly higher for the 10-μm honeycomb film than for no wrapping (P = 0.013), although no significant difference was observed between the 7-μm honeycomb and no wrapping (P = 0.085). Breaking strength for the cast film was almost equal to that for no wrapping (P = 0.994). Extra two-stitch (four-stitch) neurorrhaphy was significantly stronger than all groups, except the 10-μm honeycomb group. No significant difference was observed between the 10-μm honeycomb and the four-stitch (P = 0.497). No negative effects on functional recovery were identified. No adhesions or inflammation were observed between the film and surrounding tissues in the honeycomb groups. Honeycomb film may offer a suitable

reinforcing material for adhesion-free neurorrhaphy. © 2012 Wiley Periodicals, Inc. Microsurgery 2012. “
“The present selleck chemicals llc study was to compare the success rates of single venous anastomosis with dual venous anastomoses of the free fibula osteocutaneous flap in mandibular reconstruction. Retrospective review of all cases of mandibular reconstruction using free fibula osteocutaneous flaps performed by a single surgeon in our department during the period January 2005 to April 2012. All the flaps were harvested and transplanted by the standard protocols. Microvascular anastomosis Miconazole of either one or two veins was performed. In addition to routine clinical evaluation, the viability of the flap was evaluated by a portable Doppler at the tenth day after surgery. Two hundred and one free fibula osteocutaneous flaps

were performed during this time period. Single venous anastomosis was performed in 112 flaps and dual venous anastomoses were performed in 89 flaps. The overall incidence of vascular thrombosis was 3%, and the success rate of the transplantation was 98.5%. Six cases developed vascular thrombosis postoperatively. One was arterial thrombosis that occurred 12 hours after initial operation in the dual venous anastomoses group. Three venous thrombosis occurred 24 hr after the operation in the single venous anastomosis group. In dual venous anastomoses group, two venous thrombosis occurred 3–4 days after initial operation and attempt to salvage failed in both the cases. Fisher’s exact test showed that there was no significant difference of the success rate between single and dual anastomoses groups (P = 0.59).

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