Notably, nor Small molecule library UDCA, a side chain-shortened homologue of UDCA, improves fatty liver and atherosclerosis in Western
diet-fed ApoE(-/-) mice. Collectively, these findings suggest that BA and targeting their receptor/signaling pathways may represent a promising approach to treat NAFLD and closely linked disorders such as obesity, diabetes, dyslipidemia and arteriosclerosis. Copyright (C) 2010 S. Karger AG, Basel”
“Objectives Patients with liver cirrhosis are considered as high-risk population for cardiac surgery. The aim of this study was to review mortality and mid-term outcome of patients with liver cirrhosis requiring coronary artery bypass graft (CABG), valve replacement, or combined procedures.\n\nMethods Between July 1997 and December 2006, 47 patients (mean age 65.4 +/- 11.7 years) with liver cirrhosis were operated for CABG (21 patients), aortic valve replacement /mitral valve replacement (14 patients), CABG/VR (9 patients) or aortic dissection/tumorexstirpation (3 patients) (group I). Thirty-three patients were classified as Child-Pugh class A (subgroup A), 14 patients as Child-Pugh class B cirrhosis (subgroup B). Postoperative complications/mortality
were analyzed retrospectively and compared with a propensity-score pair-matched control group of 47 patients (group II). Follow-up ranged from 0.1 to 11.5 years (mean 3.9 +/- 0.25years) and was complete for 100%.\n\nResults Necessity of blood products was higher in group I (red cells, fresh frozen plama, platelets; P<0.01). Chest-tube output VS-4718 purchase (group I 1113 +/- 857 vs. group II 849 +/- 521; P=0.15) and re-exploration
rate (8.5 vs. 0%; P=0.11) GKT137831 cost were slightly accelerated. Ventilation time and ICU-stay was prolonged (P<0.015). Thirty-day mortality showed 19.1% (group I) versus 8.5% (group II) (P<0.01), 6.1% (subgroup A) versus 50% (subgroup B) (P<0.01). Operative risk in subgroup A was not significantly increased compared with control group (P=0.68). In Child-B operative risk was 15.5-fold higher than in Child-A cirrhosis (P<0.001). Postcardiotomy syndrome and pleurisy were more frequent in the cirrhosis group (4/47 vs. 0/47; P=0.11). Actuarial survival after 3, 5 and 8 years was: group I 78.6, 75.6, and 70.2% versus group II 89.1, 85.7, and 85.7% (P=0.08). Subgroup survival analysis was: group A 90.7, 86.6, and 78.5% versus group B 50, 50, and 50% (P<0.01).\n\nConclusion Cardiac surgery can be performed safely in patients with Child-Pugh class A and selected patients with Child-Pugh class B cirrhosis. Mid-term survival-rates within 8 years were not significantly different compared with a propensity-score pair-matched control group without cirrhosis. Eur J Gastroenterol Hepatol 22: 1466-1473 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“There is an increasing interest in assessing the relationship between climatic oscillations, environmental contaminants and the modelling of animal physiological and morphological responses.