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“The effects of particle size and parent polymer characteristics on the mechanical properties, gel fraction, and swelling index of self-crosslinkable poly(n-butyl methacrylate-co-N-methylolacrylamide) films made by two-stage emulsion or microemulsion polymerization in the presence of variable amounts of the chain transfer agent, n-butyl mercaptan, are reported here. In films prepared with latexes made by microemulsion polymerization, the crosslinking degree increased greatly on curing; by contrast, in those made by emulsion polymerization, the crosslinking degree practically did not increase after curing. GDC-0449 cell line Stress-strain tests of uncured and cured films indicate that microemulsion-made

films are tougher than the emulsion-made films. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 1669-1674, 2011″
“In this study, hot melt extrusion (HME) and KinetiSolA (R) Dispersing (KSD) were utilized to prepare dissolution-enhanced solid dispersions of Roche Research Compound A (ROA), a BCS class II drug. Preformulation characterization studies showed that ROA was Epigenetics inhibitor chemically unstable at elevated temperatures and acidic pH values. EudragitA (R) L100-55 and AQOATA (R) LF (HPMCAS) were evaluated as carrier polymers. Dispersions were characterized for ROA recovery, crystallinity, homogeneity, and non-sink dissolution. EudragitA

(R) L100-55 dispersions prepared by HME required the use of micronized ROA and reduced residence times selleck in order to become substantially amorphous. Compositions containing HPMCAS were also prepared by HME, but an amorphous dispersion could not be obtained. All HME compositions contained ROA-related impurities. KSD was investigated as a method to reduce the decomposition of ROA while rendering compositions amorphous. Substantially amorphous, plasticizer free compositions were processed successfully by KSD with significantly

higher ROA recovery values and amorphous character than those achieved by HME. A near-infrared chemical imaging analysis was conducted on the solid dispersions as a measure of homogeneity. A statistical analysis showed similar levels of homogeneity in compositions containing EudragitA (R) L100-55, while differences were observed in those containing HMPCAS. Non-sink dissolution analysis of all compositions showed rapid supersaturation after pH adjustment to approximately two to three times the equilibrium solubility of ROA, which was maintained for at least 24 h. The results of the study demonstrated that KSD is an effective method of forming dissolution-enhanced amorphous solid solutions in cases where HME is not a feasible technique.”
“The approach to the diagnosis of acute pulmonary embolism (PE) is under constant revision with advances in technology, noninvasive approaches, and increasing awareness of the risks of ionizing radiation.