The loss probabilities of oxygen and hydrogen atoms on the low-k film surface were measured for both treated and pristine films. It is shown that the film pretreatment
in He plasma leads to the noticeable densification of the top surface layer up to complete sealing all the films studied. The sealing layer prevents O atoms from deep penetration to the film bulk and carbon extraction. The sealing mechanism related to the joint impact of low-energy ions and VUV photons with metastable atoms in He plasma is discussed in detail. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3549733]“
“BACKGROUND: Cold ischemia reperfusion injury (IRI) is a major factor for early graft dysfunction and is associated with rejection episodes in heart transplantation. Clusterin (CLU) is a cytoprotective protein with chaperone
activity. This study was designed to examine the impact of donor-expressing CLU on cold IRI.
METHODS: LBH589 mouse Donor hearts from wild-type C57BL/6J (H-2(b); B6 WT) vs CLU knockout C57BL/6J (H-2(b); B6 KO) mice were stored at 4 degrees C for 8 hours, followed by heterotopic transplantation to B6 WT mice. The functional recovery AS1842856 in vitro of heart grafts was determined by scoring palpation, and tissue injury was determined by release of creatine kinase (CK) and lactate dehydrase (LDH) and also by histology.
RESULTS: Heart cells constitutively expressed CLU, and mature CLU protein was localized mostly in the endothelium as well as on the cell surface of cardiac myocytes. As compared with CLU-deficient hearts, WT hearts were more resistant to cold injury during cold preservation, and had a better functional recovery after prolonged cold preservation and transplantation. The improved graft function of CLU-expressing grafts correlated significantly with reduced neutrophil infiltration and cardiac injury, including myocytic apoptosis and necrosis. Furthermore, in vitro examination showed that ectopic expression of CLU in cultured myocytes increased cell membrane stability after exposure to cold temperature and prevented cell death.
CONCLUSIONS: CLU expression renders
donor hearts resistance to cold IRI Stem Cells & Wnt inhibitor in transplantation, suggesting that upregulation of CLU expression in donor hearts may have potential for protecting heart grafts from cold IRI. J Heart Lung Transplant 2011;30:819-26 (C) 2011 International Society for Heart and Lung Transplantation. All rights reserved.”
“Since titanium nitride appears golden and has a high conductivity, the possibility that it can be used in surface plasma wave applications in a manner similar to gold but with very strong scratch-resistance, is of interest. This work considers this possibility using the Kretschmann configuration, measuring the angle-dependent reflectivity as well as the wavelength-dependent reflectivity. Both sets of results demonstrate the excitation of a surface plasma wave at the TiN/air interface by an incident p-wave.