Our study focused primarily on the suitability of single active ingredient analgesics; however, a number of fixed-dose combination Selleckchem Tigecycline analgesics are available in the OTC setting. From a suitability perspective their

use requires even more care, making it important to ensure that consumers are aware of the potential risks associated with both active ingredients when selecting these products. Our research found no significant public health issues associated with the OTC use of paracetamol, but it has shown that up to three in 10 regular users of OTC NSAIDs have current or prior medical conditions that warrant discussion with a healthcare professional prior to their use. It is important to note that

some of these consumers may already be acting upon such advice, reducing the potential risk. However, with a large proportion of regular users of OTC NSAIDs purchasing these products outside the pharmacy setting, the quality use of OTC NSAIDs is becoming increasing reliant on product labelling and the ability of consumers to understand and self-assess their own level of risk. A key theme emanating from our data and from other recent changes in the analgesics landscape both locally and globally is the continued need to ensure a high level of consumer education RXDX-106 regarding the appropriate choice and use of analgesics. For the vast majority of consumers who have used these medications in the past the potential risks are minimal. However, consumers need to be aware that if their health status changes then this warrants a discussion with a healthcare professional to confirm the continued appropriateness of their OTC analgesic medication. Rather than placing the onus solely on the consumer to actively seek advice and hoping that this is undertaken a more practical approach would be to also reinforce with healthcare professionals

the need to proactively probe patients about the use of OTC analgesics and offer advice as to any changes that need be undertaken when they present with a new condition that puts them into an at-risk population. The safe and Mirabegron effective use of any OTC medication requires active participation and open communication between the user and healthcare professionals. Our study demonstrates that since ibuprofen has become available outside the pharmacy setting in Australia fewer people are using NSAIDs appropriately according to the label; compared to 2001, in 2009 10.2% more regular OTC analgesic users were using ibuprofen despite having contraindications, warnings, precautions or potential drug-interactions. The increasing use and wider availability of OTC NSAIDs may have led to a more relaxed attitude regarding the use of these medicines.