Pearson correlation evaluation revealed a preferable correlation between IGF-1 assessed by the two recognition techniques (r=0.94, P less then 0.01), and IGF-1 SDS ended up being also significantly correlated (r=0.92, P less then 0.01). Bland-Altman analysis showed that the consistency of serum IGF-1 levels recognized by the two techniques was poor, and also the mean difference between CLIA and MS ended up being 33.38 μg/L. The result detected by CLIA was dramatically higher than that by MS, with SDS of 43.51 μg/L (95%CI -51.89-118.7 μg/L). After changing the outcomes to SDS and getting rid of 3 outliers (including 1 GHD patient), the weighted Kappa showed appropriate consistency (κ=0.68). Conclusion In clinical application, after transforming to IGF-1 SDS, IGF-1 detected by MS and CLIA can be utilized for cross-reference, but too high or too lower levels should be cautious about.Objective to analyze the occurrence and trend of short term outcomes among preterm infants born less then 34 weeks’ gestation vaginal infection . Methods A secondary evaluation of data through the standard database established by a multicenter cluster-randomized controlled study “reduction of infection in neonatal intensive care products (NICU) using the evidence-based practice for increasing high quality (REIN-EPIQ) study”. This study had been performed in 25 tertiary NICU. A complete of 27 192 infants with gestational age less then 34 days at birth and admitted to NICU in the very first 1 week of life from May bio depression score 2015 to April 2018 were enrolled. Babies with extreme congenital malformation were excluded. Descriptive analyses were used to explain the death and major morbidities of preterm infants by gestational age groups and various entry year teams. Cochran-Armitage make sure Jonckheere-Terpstra test were utilized to investigate the trend of incidences of mortality and morbidities in 3 study-years. Multiple Logistic regression model ended up being (both P less then 0.001). Nonetheless, there have been no considerable differences in the most important morbidity in preterm babies who obtained total care through the 3-year study duration (P=0.230). After modifying for confounders, babies admitted during the 3rd study year revealed notably reduced danger of general mortality (adjust OR=0.62, 95%Cwe 0.55-0.69, P less then 0.001), mortality or significant morbidity, moderate to serious bronchopulmonary dysplasia, sepsis and severe retinopathy of prematurity, compared to those accepted in the 1st study 12 months (all P less then 0.05). Conclusions From 2015 to 2018, the mortality and major morbidities among preterm babies in Chinese NICU decreased, but there is certainly nevertheless room for further efforts. Further targeted quality improvement is necessary to improve total outcome of preterm babies.Objective To explore the worthiness of metagenomic next-generation sequencing (mNGS) in the etiology analysis of microbial meningitis in children. Techniques The etiological link between 189 kids identified as having “bacterial meningitis” or “purulent meningitis” or “central neurological system illness” in the youngsters’ Hospital of Fudan University from 1st January 2019 to 31st December 2020 had been reviewed retrospectively. The cerebrospinal fluid (CFS) for the kids with bacterial meningitis was detected by tradition and mNGS respectively, and the difference of pathogen detection price between your 2 techniques ended up being examined. Based on the age at the time of see, the kids were divided into neonatal group (≤28 times of age) and non-neonatal group (>28 times of age), and χ2 test ended up being made use of to compare the good price between the 2 teams. Taking CFS culture while the gold standard, the susceptibility and specificity of mNGS into the diagnosis of bacterial meningitis in children were reviewed. Outcomes Among these 189 kiddies with ng of microbial meningitis was 91.7%, additionally the specificity ended up being 75.0%. Conclusions The mNGS technology can improve the pathogen recognition price of bacterial meningitis in children, and has a top consistency with CSF tradition. In suspected cases where the pathogen is not identified by standard techniques, CSF mNGS is highly recommended prompt.Objective To understand the risk elements and antibiotics-resistant patterns of unpleasant Acinetobacter baumannii infection in kids. Practices This retrospective study ended up being carried out in 6 tertiary hospitals from January 2016 to December 2018. The fundamental information, clinical data and the link between antimicrobial susceptibility screening had been collected through the 98 pediatric inpatients with Acinetobacter baumannii isolated from bloodstream or cerebrospinal substance and analyzed. In line with the susceptibility for the infected strains to carbapenems, these people were divided into carbapenem-sensitive Acinetobacter baumannii (CSAB) team and carbapenem-resistant Acinetobacter baumannii (CRAB) team. In accordance with the possible sources of infection, these people were split into nosocomial infection group and community disease group. Chi-square test or Fisher precise test were used to investigate read more categorical factors and ranking sum test were utilized to assess constant factors. The risk aspects of unpleasant CRAB infection in children were analyzedtics were up to 42%-96%. Conclusions the majority of invasive Acinetobacter baumannii infection in children in China are hospital-acquired. The results of unpleasant CRAB illness was poorer than that of CSAB infection.