HypothesisHF in patients with AF is associated with
MethodsThis post hoc analysis of RealiseAF, a survey of AF patients, compared symptoms, hospitalizations, management, and AF control in patients with BTSA1 price vs without HF. A total of 10,523 AF patients were analyzed according to presence/absence of HF.
ResultsHistory of HF was present in 45.8%, and in more patients with permanent vs persistent, paroxysmal, or first-episode AF (55.6%, 44.3%, 32.9%, and 29.8%, respectively; P<0.0001). Patients with vs those without history of HF, and patients with HF and reduced ejection fraction (HF-REF) vs those with HF and a preserved ejection fraction (HF-PEF), had more frequent cardiovascular (CV) risk factors and more severe symptoms. Presence vs absence of HF, and HF-REF vs HF-PEF, were associated with lower rates of AF control (54.6% vs 62.8% and 49.3% vs 60.3%, respectively; both P<0.0001). The rate-control strategy was used more frequently in HF patients, particularly those with
HF-REF, than the rhythm-control strategy. CV hospitalizations occurred more frequently in patients with HF than those without (41.8% vs 17.5%; P<0.001) and more frequently in patients with HF-REF than in those with HF-PEF (51.6% vs 35.6%; P<0.0001).
ConclusionsAF patients with HF, particularly HF-REF, experience heavy symptom and hospitalization burdens, and have relatively Sotrastaurin low rates of AF control. Further studies are needed to identify ways to improve the management and treatment outcomes of this very high-risk patient population.”
“A part from nephrolithiasis, renal involvement is rare in the course of Crohn’s disease, particularly glomerulonephritis. On the other hand, while onset of Crohn’s disease is strongly influenced by environmental and genetic factors, little is known regarding influence of these factors on extra intestinal manifestations.
We report a familial case of glomerulonephritis that occurred in a 38-year old woman and her mother, 59 years old SHP099 with a 7-year and a 37 year history of stenosing ileocolonic disease, respectively. Both of them developed peripheral oedema with nephrotic syndrome during the course of their Crohn’s disease while they had no intestinal symptoms and were not receiving any maintenance therapy. Renal function was conserved in the former while the latter developed renal failure and had already small size kidneys on abdominal sonography. Thus, renal biopsy had been performed only in the former patient and had showed membranous glomerulonephritis. Investigations showed no other underlying disease than Crohn’s disease. Through this report we emphasis possible genetic influence on extra intestinal manifestations, particularly glomerulonephritis, in Crohn’s disease patients. (C) 2009 European Crohn’s and Collitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Objective: Exposure to radiation doses above 2 Gray (Gy) can cause skin burns.