“The concept of therapeutic vaccination represents a novel strategy of active immunotherapy that can be applied to autoimmune disease The principle is to design molecules which can trigger an immune response, targeting a cytokine that is pathogenic and over-expressed in a given disease The mostly available vaccines are an application of vaccination using either the self-protein coupled to a carrier (type I A), or a modified form of the protein engineered to include neo-epitopes (type I B) These approaches have been developed in models of several autoimmune diseases, mainly in TNF alpha-dependent
click here diseases such as rheumatoid arthritis and Crohn’s disease, but also in systemic lupus erythematosus, multiple sclerosis and myasthenia gravis Clinical trials are in progress in rheumatoid arthritis, Crohn’s disease and diabetes The benefit/risk ratio of anti-cytokine vaccination is currently under study to further develop the vaccination strategies”
“The transmission coefficient and the ballistic conductance are studied theoretically for a Dirac fermion through the graphene periodic magnetic barriers modulated by a homogeneous in-plane electric field. The transmission is highly asymmetric for zero and low biased conditions of the system. In contrast, it turns out
to be symmetric in case of strongly AZD0530 order modulated (by electric field) magnetic barriers and becomes independent of the number of barriers due to the predominant Klein tunneling effect. Interesting electric field effects are noted on the angular transmission properties of the chiral carriers. C59 wnt The conductivity profile exhibits some negative differential conducting regions, the number and the sharpness of the regions being intimately related
to the number of barriers and the Fermi energy of the system. (C) 2010 American Institute of Physics. [doi:10.1063/1.3467778]“
“Nephrogenic diabetes insipidus (NDI) secondary to chronic urinary tract obstruction is a rare condition. The exact cause is unknown; it is likely that increased collecting duct pressures cause damage to the tubular epithelium, resulting in insensitivity to the antidiuretic hormone (ADH). We report a case of NDI associated with ureteral obstruction caused by advanced stage ovarian carcioma in a 20-year-old girl. After debulcking surgery, massive polyuria continued. Several administrations of an ADH analog were ineffective in reducing urine output, suggesting a possible relationship of massive polyuria with NDI. Following oral administration of a thiazide diuretic, known to exert antidiuretic action in NDI, the urine output was dramatically reduced. This case suggests that ureteral obstruction due to ovarian mass may cause NDI and after the surgery thiazide diuretics are effective in reducing urine output in NDI with ureteral obstruction.